Choline is a constituent of sphingomyelin and lecithin. It is a precursor of acetylcholine. Choline plays a vital role in methyl group metabolism ,  carcinogenesis

and lipid transport. Choline deficiency is associated with fatty liver. It maintains cell structural integrity and cell signalling. Choline is implicated in the synthesis

of phospholipids. It acts as a potent biomarker for ischemic heart disease.

 

 

Application

Choline chloride has been used:
• in choline release assay
• as an endogenous agonist of sigma-1 receptors (Sig-1Rs)
• as a standard to analyse interrelationships between methionine and choline metabolism

Choline is an essential nutrient, commonly grouped with the B complex vitamins, that plays key roles in many biological processes. Choline, known as  Vitamin B4, is a water soluble vitamins. It plays a significant role in nutrition, but its daily requirement seems to be hundreds of times greater than that of other  vitamins.
The enzymatic activities of butyrylcholinesterase (BChE) and paraoxonase 1 (PON1), two serum enzymes synthesized by the liver and related with inflammation, were decreased in a sepsis animal model injected with LPS.
Choline chloride is added as a standard ingredient to premixes and as an additive to feed preparations for a variety of monogastric animals. Not only traditional poultry and pig feeds, but also exotic species like ostrich and sturgeon are fed with feeds supplemented with this traditional and widespread feed additive.

 


Recommended usage on basis of Choline Chloride 60% vegetable carrier (gram/mt feed)

    Pigs: 500~800
    Rabbits:1000~1700
    Cold water fish:1300~1700
    Warm water fish:500~800
    Shrimp:500~5000
    Meat chicken:500~800
    Laying hen:250~500